Non-Coding Double Stranded RNA Induces Retinoic Acid Synthesis and Retinoid Signaling to Control Regeneration
April 2019
in “
Journal of Investigative Dermatology
”
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Studysummary This study identifies a mechanism where dsRNA activates TLR3 to induce RA production, promoting hair follicle regeneration in mice and suggesting a potential role in human tissue regeneration.
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The document presents several scientific findings. One study provides the first in vivo evidence of significant positive correlations between cerebral gray matter (GM) [¹¹C]ABP688 BPND and white matter (WM) microstructural integrity in healthy subjects, which is disrupted in patients with major depressive disorder (MDD). Another study investigates the G protein's functional networks through coevolution analysis, identifying distinct sectors that compose the structural-to-functional networks of the Ga protein. A third study demonstrates that long-term potentiation (LTP) induces the translocation of microtubule-associated protein (MAP) 2 to dendritic spines of hippocampal neurons, suggesting a dynamic role for MAP2 in LTP mechanisms and synaptic remodeling. Lastly, a novel amyloid-specific gadolinium contrast agent for magnetic resonance imaging (MRI) in Alzheimer's disease mouse brain is developed, showing potential as an amyloid-MR imaging agent with amyloid beta specificity.
