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    GlossaryRetinoic Acid Signaling

    regulates gene expression through vitamin A derivatives

    Retinoic Acid Signaling, also known as RA signaling, is a biological pathway where retinoic acid, a derivative of vitamin A, binds to specific receptors in cells to regulate gene expression. This pathway is crucial for various physiological processes, including cell growth, differentiation, and embryonic development. In the context of hair biology, RA signaling can influence hair follicle development and cycling, potentially impacting conditions like alopecia.

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      learn Tretinoin

      the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

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      community Dutasteride Literally Saves Your Hair

      in Finasteride/Dutasteride  96 upvotes 6 months ago
      Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 7 months ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.