Mechanism of JmjC-Containing Protein Hairless in the Regulation of Vitamin D Receptor Function

September 2011 in “ Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ”

Yang, Mi, Ye Zhang, Yu-Fei Shen

Hairless protein vitamin D receptor VDR corepressor gene expression hair growth N-CoR transcriptional repression JmjC domain congenital alopecia hair follicle cycling HR

TLDR Hairless protein helps control hair growth by regulating vitamin D receptor activity.

The study examined the role of the Hairless (HR) protein in regulating the vitamin D receptor (VDR) function, focusing on its corepressor activity in gene expression related to hair growth. HR was found to repress VDR-mediated transactivation, with its interaction occurring in the nucleus alongside N-CoR, a transcriptional repression component. Mutations in the JmjC domain of HR impaired its corepressor function and altered its localization, leading to congenital alopecia. The study highlighted the importance of the JmjC domain and proper nuclear localization for HR's role in maintaining normal hair follicle cycling, using various cell lines and techniques to analyze these effects.

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Research cited in this study

9 / 9 results

research Hairless Is a Nuclear Receptor Corepressor Essential for Skin Function

30 citations , January 2009 in “Nuclear Receptor Signaling”

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

research Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function

143 citations , May 2007 in “Proceedings of the National Academy of Sciences”

Vitamin D receptor is crucial for normal hair growth and preventing hair loss.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research A Novel Missense Mutation Affecting the Human Hairless Thyroid Receptor Interacting Domain 2 Causes Congenital Atrichia

26 citations , October 2002 in “Journal of Investigative Dermatology”

A specific gene mutation causes congenital hair loss.

research The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor

178 citations , October 2001 in “Genes & Development”

The mutated hairless gene causes hair loss by acting as a new type of corepressor affecting thyroid hormone receptors.

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations , September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

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research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

Mechanism of JmjC-Containing Protein Hairless in the Regulation of Vitamin D Receptor Function

Research cited in this study

research Hairless Is a Nuclear Receptor Corepressor Essential for Skin Function

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

research Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

research A Novel Missense Mutation Affecting the Human Hairless Thyroid Receptor Interacting Domain 2 Causes Congenital Atrichia

research The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

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