Hairless Protein of Jumonji Family and Hair Loss
January 2009
Studysummary This article reviews the role of the hairless protein in hair cycling and gene regulation, noting the need for further understanding of its JmjC domain and subcellular localization roles.
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The hairless protein (HR), part of the jumonji family, was believed to regulate hair cycling through a stem cell-mediated process. Mutations in the Hr gene led to hair loss in both mice and humans. HR interacted with the vitamin D receptor (VDR) and histone deacetylase (HDAC) family members, acting as a nuclear receptor corepressor to regulate gene expression involved in hair cycling. However, the specific roles of the JmjC domain of HR and its subcellular localization in chromatin regulation remained unclear.
