Hairless Protein of Jumonji Family and Hair Loss

January 2009

Mi Ye

hairless protein HR Jumonji family hair cycling stem cell-mediated process Hr gene vitamin D receptor VDR histone deacetylase HDAC nuclear receptor corepressor gene expression JmjC domain chromatin regulation

TLDR Mutations in the hairless protein gene cause hair loss.

The hairless protein (HR), part of the jumonji family, was believed to regulate hair cycling through a stem cell-mediated process. Mutations in the Hr gene led to hair loss in both mice and humans. HR interacted with the vitamin D receptor (VDR) and histone deacetylase (HDAC) family members, acting as a nuclear receptor corepressor to regulate gene expression involved in hair cycling. However, the specific roles of the JmjC domain of HR and its subcellular localization in chromatin regulation remained unclear.

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