TLDR Mutations in the hairless protein gene cause hair loss.
The hairless protein (HR), part of the jumonji family, was believed to regulate hair cycling through a stem cell-mediated process. Mutations in the Hr gene led to hair loss in both mice and humans. HR interacted with the vitamin D receptor (VDR) and histone deacetylase (HDAC) family members, acting as a nuclear receptor corepressor to regulate gene expression involved in hair cycling. However, the specific roles of the JmjC domain of HR and its subcellular localization in chromatin regulation remained unclear.
30 citations
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January 2009 in “Nuclear Receptor Signaling” Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.
74 citations
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September 2006 in “Cell Cycle” The HR protein's role as a repressor is essential for controlling hair growth.
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July 2007 in “Journal of Investigative Dermatology” The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.
89 citations
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September 2010 in “Annual Review of Genomics and Human Genetics” The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.
January 2006 in “Advances in developmental biology” The Hairless gene is crucial for healthy skin and hair growth.