Hairless Protein of Jumonji Family and Hair Loss

The hairless protein (HR), part of the jumonji family, was believed to regulate hair cycling through a stem cell-mediated process. Mutations in the Hr gene led to hair loss in both mice and humans. HR interacted with the vitamin D receptor (VDR) and histone deacetylase (HDAC) family members, acting as a nuclear receptor corepressor to regulate gene expression involved in hair cycling. However, the specific roles of the JmjC domain of HR and its subcellular localization in chromatin regulation remained unclear.