Comparison of the Acute Ultraviolet Photoresponse in Congenic Albino Hairless C57BL/6J Mice Relative to Outbred SKH1 Hairless Mice
June 2016
in “
Experimental dermatology
”
ultraviolet photoresponse albino hairless mice C57BL/6J mice SKH1 hairless mice UV exposure oedema apoptosis sunburn reaction epidermal erosion scab formation myeloperoxidase activity epidermal proliferative response Ki67 immunopositivity photobiology experiments UV response hairless mice skin swelling cell death sunburn skin erosion scab MPO activity skin cell growth Ki67 photobiology
TLDR B6.Cg-Tyr c−2J Hr hr /J mice have a stronger delayed sunburn reaction and are good for UV research.
The study compared the acute UV-induced photoresponse between outbred SKH 1 hairless mice and congenic B6.Cg-Tyr c−2J Hr hr /J hairless mice. Both strains showed similar skin characteristics and initial responses to UV exposure, such as oedema and apoptosis. However, B6.Cg-Tyr c−2J Hr hr /J mice exhibited a more pronounced delayed sunburn reaction, including increased epidermal erosion, scab formation, and myeloperoxidase activity. Additionally, these mice had a suppressed epidermal proliferative response (Ki67 immunopositivity) at 24 hours post-UV exposure, unlike SKH 1 mice, which showed a significant increase in Ki67 at 72 hours post-UV. The findings suggested that B6.Cg-Tyr c−2J Hr hr /J mice are suitable for photobiology experiments.
