Comparison of the Acute Ultraviolet Photoresponse in Congenic Albino Hairless C57BL/6J Mice Relative to Outbred SKH1 Hairless Mice
April 2016
in “
Experimental dermatology
”
ultraviolet photoresponse albino hairless mice C57BL/6J mice SKH1 hairless mice UV exposure oedema apoptosis sunburn reaction epidermal erosion scab formation myeloperoxidase activity epidermal proliferative response Ki67 immunopositivity photobiology experiments UV response hairless mice skin swelling cell death sunburn skin erosion scab MPO activity skin cell growth Ki67 photobiology
TLDR B6.Cg-Tyr c−2J Hr hr /J mice have a stronger delayed sunburn reaction and are good for UV research.
The study compared the acute UVB photoresponse between congenic albino hairless C57BL/6J mice (B6.Cg-Tyrc-2J Hrhr/J) and outbred SKH1 hairless mice. Both strains showed similar initial responses to a single 1500 J/m² UVB dose, including edema and apoptosis. However, B6.Cg-Tyrc-2J Hrhr/J mice exhibited a more robust delayed sunburn reaction with increased epidermal erosion, scab formation, and myeloperoxidase activity, as well as suppressed epidermal Ki67 immunopositivity at 24 hours post-UV, unlike SKH1 mice, which showed a significant increase at 72 hours. These findings suggested that genetic background significantly impacted the photoresponse, making B6.Cg-Tyrc-2J Hrhr/J mice suitable for photobiology experiments.
