This study found that the loss of papillary fibroblasts in the skin due to UV radiation is mainly caused by an uncontrolled inflammatory response, with T cells helping fibroblast survival.
9 citations
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September 2018 in “Journal of Photochemistry and Photobiology B-biology” This study demonstrated that combining l-cystine and thiamin in a formulation may protect against UV-induced damage in growth-limited human epidermal keratinocytes in vitro.
December 2025 in “Journal of Advanced Biotechnology and Experimental Therapeutics” This study found that administering mesenchymal stem cells to UV-exposed mice reduced melanin levels, although the decrease was not statistically significant.
This study found that UV radiation-induced fibroblast depletion in the skin is primarily due to a deregulated inflammatory response, with T cells aiding fibroblast survival under stress.
20 citations
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July 2017 in “Journal of Investigative Dermatology” IL-1 receptor absence in mice leads to skin cysts and changes in immune response after UVB exposure.