Effect of Mesenchymal Stem Cells on Reducing Melanin Levels in Response to UV Radiation in Male C57BL/6 Mice

December 2025 in “ Journal of Advanced Biotechnology and Experimental Therapeutics ”

Aprilia Karen Mandagie, Viola Pramesti, Sugeng Ibrahim, Indra Adi Susianto

mesenchymal stem cells melanin UV radiation skin hypermelanosis

TLDR Mesenchymal stem cells may help reduce melanin in UV-exposed mice.

This study investigated the effect of mesenchymal stem cells (MSC) on melanin levels in male C57BL/6 mice exposed to UV radiation. The mice were divided into three groups: normal, UV, and UV+MSC. The results indicated that MSC therapy reduced melanin levels in UV-exposed mice, although the reduction was not statistically significant at a dose of 0.1 cc. Histopathological analysis confirmed the decrease in melanin levels. The study suggests that MSC could be a potential alternative strategy for preventing skin hypermelanosis in UV-exposed mice.

View this study on jb-media.bsmiab.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Update on Melasma—Part I: Pathogenesis

10 citations , July 2022 in “Dermatology and Therapy”

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

research The Melanocyte Photosensory System in Human Skin

11 citations , April 2013 in “SpringerPlus”

Human skin's melanocytes respond to light by changing shape, producing pigments and hormones, which may affect sleep patterns.

research Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata

26 citations , June 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Regenerative therapies show promise for treating vitiligo and alopecia areata.

research Aging and Anti-Aging in Hair and Hair Loss

1 citations , September 2013 in “Elsevier eBooks”

Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.

research 8th International Conference: Interdisciplinary Aspects of Diseases of the Skin and Mucous Membranes, March 11-12, 2022

January 2022 in “Dermatology Review”

Higher IL-31 levels are linked to worse itching in chronic kidney disease patients.

Effect of Mesenchymal Stem Cells on Reducing Melanin Levels in Response to UV Radiation in Male C57BL/6 Mice

Related Community Posts Join

community This guy claims stem cells fixed his balding

community Microneedling and aloe vera to recruit stem cells.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

community Anyone Try Microneedling with Exosomes/AAPE?

community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

community New and Interesting HairLoss Studies/Papers/Reviews