Cystine-Thiamin-Containing Hair-Growth Formulation Modulates the Response to UV Radiation in an In Vitro Model for Growth-Limiting Conditions of Human Keratinocytes

    September 2018 in “ Journal of Photochemistry and Photobiology B-biology ”
    Thomas Hengl, Jörn Herfert, Alexander Soliman, Kim Schlinzig, Ralph M. Trüeb, Harry F. Abts
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    TLDR A hair-growth formula with cystine and thiamin helps protect skin cells against UV damage and improves their growth.
    The study from December 2018 explored the impact of a cystine-thiamin-containing hair-growth formulation (P-IC) on the response of human keratinocytes to UV radiation in vitro. The research demonstrated that L-cystine and thiamin, components of P-IC, significantly increased the metabolic activity and proliferation of normal human epidermal keratinocytes (NHEKs) cultured in a minimal growth medium (MGM). The combination of ingredients in P-IC was more effective than individual components, leading to a four-fold increase in metabolic activity and a three-fold increase in proliferation. Furthermore, P-IC-treated cells showed a substantially lower reduction in metabolic activity after UV irradiation compared to cells in MGM alone, indicating a protective effect against UV-induced damage that was not due to UV filtering. The study concluded that P-IC could be beneficial for hair and scalp protection against environmental stressors like UV radiation, suggesting a potential UV-protective role for hair-growth formulations containing these ingredients. The document also notes the authors' affiliation with Merz Pharmaceuticals GmbH.
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