Xenobiotics In Vitro: The Influence of L-Cystine, Pantothenate, and Miliacin on Metabolic and Proliferative Capacity of Keratinocytes

    January 2006 in “ Cutaneous and ocular toxicology ”
    D. Hoeller Obrigkeit, T Oepen, Frank K. Jugert, Hans F. Merk, Janusz Kubicki
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    TLDR L-cystine, D-pantothenat, and miliacin together significantly boost keratinocyte growth and metabolism.
    The study investigated the effects of L-cystine, D-pantothenat, and miliacin on human epidermal keratinocytes. In deficient medium, keratinocytes showed a 35% reduction in metabolic capacity and no measurable proliferation. L-cystine restored metabolic capacity up to 92%, D-pantothenat increased it to 150% in fully supplemented medium, and miliacin enhanced both metabolic capacity (162%) and cell proliferation (215%). The combination of all three additives synergistically increased metabolic capacity to 245%. These findings suggested that these substances, particularly in combination, could beneficially affect keratinocyte growth and are suitable for pharmacological testing, as demonstrated by the hair growth drug PRIORIN®.
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