Androgenetic Alopecia in Heterozygous Carriers of a Mutation in the Human Hairless Gene

June 2000 in “ Journal of The American Academy of Dermatology ”

Eli Sprecher, Adel Shalata, Kamal Dabhah, Boris Futerman e, Shai Lin, Raymonde Szargel, Reuven Bergman, Rachel Friedman-Birnbaum, Nadine Cohen

androgenetic alopecia hairless gene hair follicles genetic testing mutation hair growth hair development AGA genetic testing

TLDR Mutation in hairless gene may increase hair loss risk.

This document is a collection of summaries of various studies on the relationship between the hairless gene and androgenetic alopecia (AGA). The studies suggest that carrying a mutation in the hairless gene may increase the likelihood of developing AGA, but more research is needed to fully understand the role of this gene in hair loss. The hairless gene is important for hair growth and development, and disruption of this gene can prevent hair follicles from starting a new cycle. The studies emphasize the need for genetic testing in individuals with a family history of hair loss to identify carriers of the mutation.

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Research cited in this study

4 / 4 results

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

126 citations, October 1998 in “Experimental Dermatology”

The hr gene is crucial for skin and hair health, with mutations causing hair disorders.

research Fortnightly Review: Male Pattern Androgenetic Alopecia

179 citations, September 1998 in “BMJ”

Hair loss in men is common, treatable, but not curable.

research Male Pattern Hair Loss: Current Understanding

59 citations, August 1998 in “International Journal of Dermatology”

Genetics and hormones cause hair loss; finasteride treats it safely.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations, July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Related Community Posts Join

6 / 1000+ results

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 2 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 160 upvotes 1 year ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community When are we getting a cure to hair loss?

in Chat 1 year ago

Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

community How do we only have two treatments to combat hair loss at this point in time?

in Chat 211 upvotes 1 year ago

The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

in Research/Science 104 upvotes 4 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community Please stop looking for a natural way to stop your hairloss

in Chat 247 upvotes 2 years ago

There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

Related Research

1 / 1 results

research Androgenetic Alopecia in Heterozygous Carriers of a Mutation in the Human Hairless Gene

9 citations, June 2000 in “Journal of The American Academy of Dermatology”

Mutation in hairless gene may increase hair loss risk.