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Glossary Hairless Phenotype

genetic condition causing absence or reduction of body hair

The hairless phenotype refers to a genetic condition where an individual lacks hair on their body or has significantly reduced hair growth. This can be due to mutations in specific genes that are responsible for hair development and maintenance. In both humans and animals, this phenotype can result from various genetic disorders or be a naturally occurring trait in certain breeds or species.

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Research

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research Towards Defining the Pathogenesis of the Hairless Phenotype

86 citations , June 1998 in “Journal of Investigative Dermatology”

This study found that mutations in the hairless gene in mice disrupt hair follicle integrity during catagen, leading to baldness due to disintegrating epithelial structures and loss of normal dermal papilla.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

research Intragenic deletion in the Desmoglein 4 gene underlies the skin phenotype in the Iffa Credo “hairless” rat

28 citations , October 2004 in “Differentiation”

This study identified a large deletion in the desmoglein 4 gene as the genetic basis of the Iffa Credo "hairless" rat's skin phenotype, linking it to lanceolate hair mutations.

Taking Advantage of Phenotype Variability in a Local Animal Genetic Resource: Identification of Genomic Regions Associated with the Hairless Phenotype in Casertana Pigs

research Taking advantage from phenotype variability in a local animal genetic resource: identification of genomic regions associated with the hairless phenotype in Casertana pigs

16 citations , April 2018 in “Animal Genetics”

This study identified two significant genomic regions potentially involved in hair development and growth in Casertana pigs, highlighting FOXN3 and ARHGEF10 as candidate genes associated with a hairless phenotype.

research Pathobiology of the hairless phenotype: Dysregulation of hair follicle apoptosis and topobiology during the initiation of follicle cycling

9 citations , March 1998 in “Journal of Dermatological Science”

Improper regulation of hair follicle processes causes hairlessness.

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community can these ingredients reverse hairloss?

1 upvotes 4 years ago

The post discusses skepticism about a "miracle hair cream" claiming to reverse hair loss, with the user already using finasteride, minoxidil, and dermastamping. The cream's ingredients include various oils and acids, but the user seeks confirmation of its effectiveness.

community a hair cream that claims to reverse hairloss. need ur opinion guys

1 upvotes 4 years ago

A user is skeptical about a "miracle hair cream" claiming to reverse hair loss and seeks opinions on its effectiveness. They are already using finasteride, minoxidil, and dermastamping weekly but want additional help for temple hair growth.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Sugar and Hair loss connections

in Research/Science 41 upvotes 1 year ago

High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

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