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    Glossary Hairless Phenotype

    genetic condition causing absence or reduction of body hair

    The hairless phenotype refers to a genetic condition where an individual lacks hair on their body or has significantly reduced hair growth. This can be due to mutations in specific genes that are responsible for hair development and maintenance. In both humans and animals, this phenotype can result from various genetic disorders or be a naturally occurring trait in certain breeds or species.

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    1. Towards Defining the Pathogenesis of the Hairless Phenotype Journal of Investigative Dermatology · 1998 · 86 citations
    2. Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Investigative Dermatology · 2001 · 54 citations
    3. Intragenic deletion in the Desmoglein 4 gene underlies the skin phenotype in the Iffa Credo “hairless” rat Differentiation · 2004 · 28 citations
    4. Taking advantage from phenotype variability in a local animal genetic resource: identification of genomic regions associated with the hairless phenotype in Casertana pigs Animal Genetics · 2018 · 16 citations
    5. Pathobiology of the hairless phenotype: Dysregulation of hair follicle apoptosis and topobiology during the initiation of follicle cycling Journal of Dermatological Science · 1998 · 9 citations
    6. The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-kb Genomic DNA Containing Five Basic Keratin Genes Journal of Biological Chemistry · 2008 · 35 citations
    7. Characterization of hairless (Hr) and FGF5genes provides insights into the molecular basis of hair loss in cetaceans BMC evolutionary biology · 2013 · 50 citations
    8. Unraveling the Molecular Mechanisms of Hair and Nail Genodermatoses Archives of Dermatology · 2001 · 23 citations
    9. Thehairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype Developmental Dynamics · 1999 · 52 citations
    10. A homozygous single T deletion found in the GGCX gene with PXE-like phenotypes Journal of Dermatological Science · 2016
    11. Increased rate of hair keratin gene loss in the cetacean lineage BMC Genomics · 2014 · 42 citations
    12. THE EXPRESSION AND INTERACTION OF HEREDITARY FACTORS PRODUCING HYPOTRICHOSIS IN THE MOUSE: HISTOLOGY AND EXPERIMENTAL RESULTS 1946 · 40 citations
    13. Comparative genomics analyses of alpha-keratins reveal insights into evolutionary adaptation of marine mammals Frontiers in Zoology · 2017 · 25 citations
    14. iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice PLoS ONE · 2014 · 15 citations
    15. A mutation in MAP2 is associated with prenatal hair follicle density The FASEB Journal · 2019 · 11 citations
    16. The “Bald Mill Hill” Mutation in the Mouse Is Associated with an Abnormal, Mislocalized HR bmh Protein Journal of Investigative Dermatology · 2007 · 1 citations
    17. A missense mutation in Lama3 causes androgen alopecia Scientific Reports · 2023
    18. Reply Journal of Investigative Dermatology · 2000 · 2 citations
    19. Atrichia with Papular Lesions in a Chinese Family Caused by Novel Compound Heterozygous Mutations and Literature Review Dermatology · 2013 · 3 citations
    20. Reply Journal of Investigative Dermatology · 2000 · 1 citations
    21. Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed Genes · 2020 · 27 citations
    22. Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor<sup>†</sup> Photochemistry and photobiology · 2008 · 10 citations
    23. The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71 Mammalian genome · 2010 · 75 citations
    24. Weathering of the hairless scalp: a study using skin capacitance imaging and ultraviolet light-enhanced visualization Clinical and Experimental Dermatology · 2009 · 19 citations
    25. A novel missense mutation in the mouse hairless gene causes irreversible hair loss: Genetic and molecular analyses of Hrm1Enu Genomics · 2006 · 18 citations
    26. Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis Experimental Dermatology · 2013 · 10 citations
    27. Analyse de la régulation du gène Hairless et identification des voies de signalisation affectées chez les mutants «bald Mill Hill». HAL (Le Centre pour la Communication Scientifique Directe) · 2008
    28. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    29. The mouse frizzy (<i>fr</i>) and rat ‘hairless’ (<i>fr</i><sup><i>CR</i></sup>) mutations are natural variants of protease serine S1 family member 8 (<i>Prss8</i>) Experimental Dermatology · 2010 · 28 citations
    30. Insertional mutation of the hairless locus on mouse Chromosome 14 Mammalian Genome · 1993 · 19 citations