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    Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed

    May 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    R. Buckley, Barbara Gandolfi, Erica K. Creighton … Leslie A. Lyons

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, researchers identified loss of function variants in the HR gene as likely causes of the distinct roaning hair coat seen in lykoi cats.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. A Frameshift Insertion in SGK3 Leads to Recessive Hairlessness in Scottish Deerhounds: A Candidate Gene for Human Alopecia Conditions Human Genetics · 2019
    2. A Splice Variant in KRT71 Is Associated with Curly Coat Phenotype of Selkirk Rex Cats Scientific Reports · 2013
    3. Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into the Molecular Basis of Hair Loss in Cetaceans BMC evolutionary biology · 2013
    4. The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71 Mammalian genome · 2010
    5. Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis Nature Genetics · 2009
    6. Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats Journal of Heredity · 2007
    7. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    8. A Novel Missense Mutation Affecting the Human Hairless Thyroid Receptor Interacting Domain 2 Causes Congenital Atrichia Journal of Investigative Dermatology · 2002
    9. Atrichia With Papular Lesions Resulting From Mutations In The Rhesus Macaque (Macaca Mulatta) Hairless Gene Laboratory Animals · 2002
    10. The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor Genes & Development · 2001
    11. A Novel Missense Mutation (C622G) in the Zinc-Finger Domain of the Human Hairless Gene Associated with Congenital Atrichia with Papular Lesions Experimental Dermatology · 2000
    12. Alopecia Universalis Associated With a Mutation in the Human Hairless Gene Science · 1998

    Related research 4

    1. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
    2. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    3. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene Journal of biological chemistry/˜The œJournal of biological chemistry · 2012
    4. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001