A Missense Mutation in Lama3 Causes Androgen Alopecia

November 2023 in “ Scientific Reports ”

Zhong-Hao Ji, Wenzhi Ren, Song He, Wu H, Bao Yuan, Jian Chen, Haixia Jin

Lama3 androgenetic alopecia AGA laminin-332 CRISPR/Cas9 hair dynamic homeostasis gene mutation hairless phenotype CRISPR

Studysummary In this study, researchers used NIH hairless mice to uncover genetic markers associated with hair loss and identified a Lama3 point mutation as a potential genetic contributor, creating a mutant mouse model that may advance the study of androgenetic alopecia.

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