The First Broad Replication Study of SNPs and a Pilot Genome-Wide Association Study for Androgenetic Alopecia in Asian Populations
June 2022
in “
Journal of Cosmetic Dermatology
”
TLDR Two specific genetic markers increase the risk of hair loss in Asian populations.
This study aimed to confirm known susceptibility genes and identify additional candidate genes for androgenetic alopecia (AGA) in the Korean population. It involved 494 individuals, including 275 AGA cases and 146 controls. Using a precision medical research array and imputation-based SNPs, the study examined 62,160 SNPs. Results showed 1,143 SNPs in 76 gene regions with weak replication tendencies and 110 SNPs in 13 independent regions with suggestive p-values. The most significant SNP was on chromosome 20, aligning with other studies. The study identified two SNPs (rs11010734 and rs2420640) that increase AGA risk, providing a reference for non-European studies to understand AGA in different populations.