Prediction of Male-Pattern Baldness from Genotypes

October 2015 in “ European Journal of Human Genetics ”

Fan Liu, Merel A. Hamer, Stefanie Heilmann, Christine Herold, Susanne Moebus, Albert Hofman, André G. Uitterlinden, Markus M. Nöthen, Cornelia M. van Duijn, Tamar Nijsten, Manfred Kayser

male-pattern baldness MPB genetic data logistic regression model single-nucleotide polymorphisms SNPs genomic loci early-onset MPB autosomal SNPs X-chromosome SNPs baldness genetic markers genetic prediction

Studysummary This study found that a genetic model using SNPs can predict early-onset male-pattern baldness with moderate accuracy, which may assist in decisions about interventions.

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research The Rotterdam Study: 2014 Objectives and Design Update

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research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

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research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

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This study found that early-onset androgenetic alopecia in individuals of European ancestry is significantly associated with increased odds of Parkinson's disease and is influenced by specific genetic loci, including some linked to reduced fertility.

research Characteristics of Androgenetic Alopecia in Asian Populations

51 citations , January 2012 in “Annals of Dermatology”

This review discusses characteristics of androgenetic alopecia in Asian patients and includes algorithmic management guidelines, but reports no new clinical findings.

research Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness

51 citations , November 2011 in “British Journal of Dermatology”

This study suggests that the HDAC9 gene is a third susceptibility gene for male-pattern baldness, with significant associations found in both German and Australian samples.

research Improving Human Forensics Through Advances in Genetics, Genomics, and Molecular Biology

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research Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11

140 citations , October 2008 in “Nature Genetics”

research Male-Pattern Baldness Susceptibility Locus at 20p11

111 citations , October 2008 in “Nature Genetics”

In their study, Tim Spector and colleagues identified a new genetic association at chromosome 20p11.22 with male-pattern baldness, confirmed by the increased risk when combined with a known androgen receptor gene variant.

research EDA2R Is Associated With Androgenetic Alopecia

82 citations , April 2008 in “Journal of Investigative Dermatology”

EDA2R gene linked to hair loss.

research The Rotterdam Study: Objectives And Design Update

1415 citations , October 2007 in “European Journal of Epidemiology”

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research Validity of Self-Reported Male Balding Patterns in Epidemiological Studies

32 citations , December 2004 in “BMC Public Health”

This study found that trained observers using the Hamilton-Norwood classification were very reliable in assessing balding patterns, while men's self-assessments were moderately accurate compared to observers.

research Genetic Basis of Male Pattern Baldness

191 citations , December 2003 in “Journal of Investigative Dermatology”

Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.

research Male Androgenetic Alopecia

54 citations , July 2002 in “Clinical and Experimental Dermatology”

This article provides a critical overview of recent discoveries in the genetics and molecular processes involved in androgenetic alopecia, focusing on its polygenic basis and DHT dependency, but reports no new clinical results.