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research Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology

June 2013 in “Faculty of Health; Institute of Health and Biomedical Innovation”

Four genetic risk areas related to male-pattern baldness were identified, with WNT signaling playing a role in its development.

research MendelVar: Gene Prioritization at GWAS Loci Using Phenotypic Enrichment of Mendelian Disease Genes

2 citations, April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.

research Mapping of Cis-Acting Expression Quantitative Trait Loci in Human Scalp Hair Follicles

4 citations, November 2020 in “BMC Dermatology”

Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.

research Prediction of Male-Pattern Baldness from Genotypes

37 citations, October 2015 in “European Journal of Human Genetics”

Genetic data can predict male-pattern baldness with moderate accuracy, especially for early-onset cases in some European men.

research Alopecia Areata: A Review of Diagnosis, Pathogenesis, and the Therapeutic Landscape

March 2022 in “Wound practice & research”

New treatments for alopecia areata show promise, but standardized guidelines are needed.

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community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 2 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 7 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Fagron TrichoTest says Finasteride won't help

in Treatment 13 upvotes 4 months ago

The user received a Fagron TrichoTest indicating that Finasteride, Dutasteride, and Minoxidil are not effective for them, recommending Latanoprost, Spironolactone, IGrantine-F1 TM, and Trichoxidil instead. Other users expressed skepticism about the test's validity and suggested sticking with proven treatments like Finasteride and Dutasteride.