Laminin-511, Inducer of Hair Growth, Is Down-Regulated and Its Suppressor in Hair Growth, Laminin-332 Up-Regulated in Chemotherapy-Induced Alopecia

April 2010 in “ Journal of dermatological science ”

Hiroyasu Imanishi, Daisuke Tsuruta, Chiharu Tateishi, Koji Sugawara, Ralf Paus, Tsutomu Tsuji, Masamitsu Ishii, Kazuo Ikeda, Hiroyuki Kunimoto, Kōichi Nakajima, Jonathan Jones, Hiromi Kobayashi

laminin-511 laminin-332 chemotherapy-induced alopecia CIA hair growth hair loss cyclophosphamide apoptosis hair matrix cells hair follicles chemotherapy-induced hair loss cell death hair roots

Studysummary This study reports that chemotherapy-induced alopecia in mice may be linked to decreased laminin-511 and increased laminin-332 around hair follicles, suggesting a potential mechanism for abrupt hair loss. Our plain-language summary of this paper — not a Tressless recommendation.

The study concluded that in chemotherapy-induced alopecia (CIA), laminin-511, which promotes hair growth, was down-regulated, while laminin-332, which suppresses hair growth, was up-regulated. This inverse relationship suggested a potential mechanism for hair loss caused by chemotherapy. Using a mouse model treated with cyclophosphamide, researchers found that injecting laminin-511-rich protein extracts delayed hair loss and promoted hair growth by preventing apoptosis in hair matrix cells. The study involved approximately 350 hair follicles in 9 mice and 36 human hair follicles, providing a robust dataset for these findings.

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research Spatial And Temporal Control Of Laminin-511 And -332 Expressions During Catagen

6 citations , April 2010 in “Journal of Dermatological Science”

This study observed that downregulation of laminin-511 plays an important role in hair regression during the catagen stage in mice.

research Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis

102 citations , August 2008 in “Genes & Development”

This study found that laminin-511 is crucial for hair morphogenesis in mice, as it influences primary cilia formation and dermal papilla maintenance through noggin and sonic hedgehog signaling.

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations , November 2007 in “American Journal of Pathology”

In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.

research Dissecting the Impact of Chemotherapy on the Human Hair Follicle

99 citations , September 2007 in “The American journal of pathology”

This study found that organ-cultured human scalp hair follicles can mimic chemotherapy-induced damage in vivo and serve as a model to explore molecular targets and protective agents for hair follicle preservation.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations , December 2006 in “The American journal of pathology”

This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

This study defines classification criteria for hair follicle dystrophy using a mouse model of chemotherapy-induced alopecia, providing tools for standardized hair damage assessment.

research α3β1-Integrin Regulates Hair Follicle But Not Interfollicular Morphogenesis in Adult Epidermis

45 citations , May 2003 in “Journal of Cell Science”

This study found that α3β1-integrin is crucial for maintaining normal hair follicle morphology in mice, as its deficiency leads to severe abnormalities despite not affecting interfollicular epidermal differentiation.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations , January 2001 in “Science”

In a neonatal rat model, this study found that topical CDK2 inhibitors reduced chemotherapy-induced hair loss in 33 to 50% of the animals, suggesting a potential strategy for preventing alopecia in cancer patients.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations , April 2000 in “The American journal of pathology”

This study found that overexpressing human Bcl-2 in mice protected epidermal keratinocytes from UVB-induced apoptosis but unexpectedly increased apoptosis during hair follicle regression and chemotherapy.

research Hair Follicle Apoptosis And Bcl-2

54 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

53 citations , October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that cyclophosphamide induced significant keratinocyte apoptosis in anagen hair follicles of mice, while topical calcitriol-analogs reduced this apoptosis, suggesting a protective effect against chemotherapy-induced alopecia.

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

127 citations , July 1996 in “Journal of The American Academy of Dermatology”

This study found that in women undergoing chemotherapy after breast surgery, topical minoxidil significantly shortened the duration of hair loss compared to a placebo without significant side effects.

research Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia

49 citations , October 1994 in “Annals of Oncology”

Minoxidil not effective in preventing chemotherapy-induced hair loss.

Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations , April 1994 in “PubMed”

This study introduces a mouse model of cyclophosphamide-induced alopecia, which effectively replicates human chemotherapy-induced hair loss and can be pharmacologically manipulated to study hair regrowth patterns.

research Scalp Cooling Has No Place in the Prevention of Alopecia in Adjuvant Chemotherapy for Breast Cancer

39 citations , January 1994 in “European Journal of Cancer”

In this study, scalp hypothermia with the Theracool™ cooling machine was largely ineffective for preventing alopecia in breast cancer patients undergoing a chemotherapeutic regimen including cyclophosphamide and anthracyclines.

research The Use of Minoxidil to Prevent Alopecia During Chemotherapy for Gynecologic Malignancies

36 citations , January 1991 in “PubMed”

In this pilot study, 2% topical Minoxidil showed no benefit in preventing hair loss during chemotherapy for gynecologic cancers, although it was non-toxic.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.

research High-Dose Alpha-Tocopherol as a Preventive of Doxorubicin-Induced Alopecia

18 citations , October 1986 in “PubMed”

This study found that alpha-tocopherol acetate did not demonstrate any protective effect against hair loss induced by doxorubicin in patients with solid tumors.

research Prevention of Doxorubicin-Induced Alopecia by Scalp Hypothermia: Relation to Degree of Cooling

53 citations , June 1982 in “The BMJ”

Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.