Laminin-511, Inducer of Hair Growth, Is Down-Regulated and Its Suppressor in Hair Growth, Laminin-332 Up-Regulated in Chemotherapy-Induced Alopecia

    Hiroyasu Imanishi, Daisuke Tsuruta, Chiharu Tateishi, Koji Sugawara, Ralf Paus, Tsutomu Tsuji, Masamitsu Ishii, Kazuo Ikeda, Hiroyuki Kunimoto, Kōichi Nakajima, Jonathan Jones, Hiromi Kobayashi
    TLDR Chemotherapy-induced hair loss is partly due to decreased laminin-511 and increased laminin-332.
    The study concluded that in chemotherapy-induced alopecia (CIA), laminin-511, which promotes hair growth, was down-regulated, while laminin-332, which suppresses hair growth, was up-regulated. This inverse relationship suggested a potential mechanism for hair loss caused by chemotherapy. Using a mouse model treated with cyclophosphamide, researchers found that injecting laminin-511-rich protein extracts delayed hair loss and promoted hair growth by preventing apoptosis in hair matrix cells. The study involved approximately 350 hair follicles in 9 mice and 36 human hair follicles, providing a robust dataset for these findings.
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