Laminin-511, Inducer of Hair Growth, Is Down-Regulated and Its Suppressor in Hair Growth, Laminin-332 Up-Regulated in Chemotherapy-Induced Alopecia

April 2010 in “ Journal of dermatological science ”

Hiroyasu Imanishi, Daisuke Tsuruta, Chiharu Tateishi, Koji Sugawara, Ralf Paus, Tsutomu Tsuji, Masamitsu Ishii, Kazuo Ikeda, Hiroyuki Kunimoto, Kōichi Nakajima, Jonathan Jones, Hiromi Kobayashi

TLDR Chemotherapy-induced hair loss is partly due to decreased laminin-511 and increased laminin-332.

The study concluded that in chemotherapy-induced alopecia (CIA), laminin-511, which promotes hair growth, was down-regulated, while laminin-332, which suppresses hair growth, was up-regulated. This inverse relationship suggested a potential mechanism for hair loss caused by chemotherapy. Using a mouse model treated with cyclophosphamide, researchers found that injecting laminin-511-rich protein extracts delayed hair loss and promoted hair growth by preventing apoptosis in hair matrix cells. The study involved approximately 350 hair follicles in 9 mice and 36 human hair follicles, providing a robust dataset for these findings.

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research Spatial And Temporal Control Of Laminin-511 And -332 Expressions During Catagen

6 citations , April 2010 in “Journal of Dermatological Science”

Laminin-511 may help promote hair growth, while laminin-332 does not affect hair loss.

research Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis

102 citations , August 2008 in “Genes & Development”

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations , December 2007 in “American Journal of Pathology”

Stress-related substance P may lead to hair loss and negatively affect hair growth.

research Dissecting the Impact of Chemotherapy on the Human Hair Follicle

99 citations , October 2007 in “The American journal of pathology”

Chemotherapy damages hair follicles, causing hair loss and other cellular changes.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations , December 2006 in “The American journal of pathology”

Edar signaling is crucial for controlling hair growth and regression.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , July 2005 in “Journal of Investigative Dermatology”

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

research α3β1-Integrin Regulates Hair Follicle But Not Interfollicular Morphogenesis in Adult Epidermis

45 citations , July 2003 in “Journal of Cell Science”

α3β1-integrin is crucial for maintaining normal hair follicle shape and function but not needed for the development of the surrounding skin.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations , January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations , April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations , April 1994 in “PubMed”

Cyclosporine A slows down hair loss from chemotherapy in mice, while dexamethasone increases hair loss but speeds up regrowth.

research Scalp Cooling Has No Place in the Prevention of Alopecia in Adjuvant Chemotherapy for Breast Cancer

39 citations , January 1994 in “European Journal of Cancer”

Scalp cooling is largely ineffective in preventing hair loss from breast cancer chemotherapy.

research Prevention of Doxorubicin-Induced Alopecia by Scalp Hypothermia: Relation to Degree of Cooling

53 citations , June 1982 in “The BMJ”

Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.