High-Dose Alpha-Tocopherol as a Preventive of Doxorubicin-Induced Alopecia

    October 1986 in “ PubMed ”
    Pérez García Je, M Macchiavelli, B Leone, Alfonso E. Romero, Rabinovich Mg, D Goldar, Carlos Vallejo
    TLDR Alpha-tocopherol does not prevent hair loss from doxorubicin.
    A study conducted on 20 patients with various solid tumors evaluated the effectiveness of alpha-tocopherol acetate in preventing doxorubicin-induced alopecia. Despite receiving doxorubicin at doses of 50-60 mg/m2 per treatment cycle, 90% of the patients experienced severe hair loss, while 10% had moderate hair loss. The trial concluded that alpha-tocopherol showed no protective activity against hair loss in these patients.
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