Expression of Foxi3 Is Regulated by Ectodysplasin in Skin Appendage Placodes

February 2013 in “ Developmental dynamics ”

Vera Shirokova, Maria Jussila, Marjo K. Hytönen, Nina Perälä, Cord Drögemüller, Tosso Leeb, Hannes Lohi, Kirsi Sainio, Irma Thesleff, Marja L. Mikkola

Foxi3 ectodysplasin Eda pathway activin A hair follicles hypohidrotic ectodermal dysplasia HED embryonic skin explants

Studysummary This study found that Eda and activin A regulate Foxi3 expression, which may contribute to the development of hypohidrotic ectodermal dysplasia by affecting Foxi3 activity in ectodermal appendages like hair and teeth.

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research Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

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research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

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research The Hair Follicle as a Dynamic Mini-Organ

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This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

research TNF Superfamily in Skin Appendage Development

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This review discusses recent discoveries about the role of Eda and other TNF-related cytokines in skin appendage development and reports no new experimental results, highlighting developments since the last comprehensive summary in 2003.

research Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes

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This study identified that Eda-A1 unexpectedly induces placode inhibitors dkk4 and lrp4, indicating the importance of tightly regulated signaling for proper ectodermal organ development.

Significant Correction of Disease After Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia

research Significant Correction of Disease After Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia

109 citations , October 2007 in “American Journal of Human Genetics”

This study found that postnatal treatment with recombinant EDA normalized adult teeth, improved sweating, and restored normal lacrimation in dogs with XLHED, suggesting its potential as a treatment for the condition.

research Genetic Basis of Skin Appendage Development

111 citations , January 2007 in “Seminars in cell & developmental biology”

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research Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis

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research Identification of a Secreted BMP Antagonist, Ectodin, Integrating BMP, FGF, and SHH Signals from the Tooth Enamel Knot

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research Stimulation of Ectodermal Organ Development by Ectodysplasin-A1

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