Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

January 2012 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Sylvie Lefebvre, Ingrid Fliniaux, Pascal Schneider, Marja L. Mikkola

Ectodysplasin Eda Edar NF-κB hypohidrotic ectodermal dysplasia HED Fc-Eda protein Wnt fibroblast growth factor Tnf chemokine ligands cxcl10 cxcl11 chemokine receptor cxcR3 primary hair follicle density primary hair placodes NF-kappa B

Studysummary This study identified chemokine receptor ligands cxcl10 and cxcl11 as new hair-specific transcriptional targets of the Eda pathway, suggesting chemokine signaling plays a role in primary hair follicle patterning. Our plain-language summary of this paper — not a Tressless recommendation.

The study identified that Ectodysplasin (Eda) regulated skin appendage morphogenesis through its receptor Edar and transcription factor NF-κB, with mutations in this pathway causing hypohidrotic ectodermal dysplasia (HED) characterized by sparse hair and other abnormalities. Using microarray profiling on embryonic skin explants exposed to recombinant Fc-Eda protein, researchers found that Eda influenced multiple signaling pathways, including Wnt, fibroblast growth factor, and Tnf. Notably, they discovered that chemokine ligands cxcl10 and cxcl11 were new hair-specific transcriptional targets of Eda. A deficiency in the chemokine receptor cxcR3 led to decreased primary hair follicle density, suggesting that chemokine signaling played a role in the patterning of primary hair placodes.

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