Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation

    September 2010 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Andrey A. Sharov, Mandy Schroeder, Tatyana Sharova … Vladimir A. Botchkarev
    Studysummary This study suggests that MMP-9 plays a significant role in extracellular matrix remodeling during hair canal formation in mice, as indicated by delayed hair shaft emergence and hair canal development in MMP-9 knockout mice.
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    Research cited in this study 5

    1. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    2. Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation EMBO journal · 2003
    3. Identification of Clustered Cells in Human Hair Follicle Responsible for MMP-9 Gelatinolytic Activity: Consequences for the Regulation of Hair Growth International Journal of Dermatology · 2001
    4. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin: The Absence of Type VII Collagen Is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000
    5. Correlation of Proteolytic Activities of Organ Cultured Intact Mouse Skin With Defined Hair Cycle Stages Journal of Dermatological Science · 1994