Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation

    June 2003 in “ EMBO journal ”
    Andrey A. Sharov, Lorin Weiner, Tatyana Sharova … Vladimir A. Botchkarev
    Studysummary This study reports that overexpressing the BMP antagonist noggin in mice inhibits eyelid opening by reducing apoptosis and delaying cell differentiation in the eyelid epithelium.
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    Research cited in this study 6

    1. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003
    2. Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues The EMBO Journal · 2002
    3. Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis EMBO journal · 2001
    4. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    5. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    6. Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair EMBO journal · 1999