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    Glossary BMP antagonist

    substance that inhibits Bone Morphogenetic Protein activity

    A BMP antagonist, also known as a Bone Morphogenetic Protein antagonist, is a substance that inhibits the activity of BMPs, which are proteins involved in the regulation of cell growth, differentiation, and development. By blocking BMP signaling, these antagonists can influence various biological processes, including bone formation and hair growth, making them relevant in medical research and treatments for conditions like alopecia and bone disorders.

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    1. Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot Developmental biology · 2003 · 243 citations
    2. Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin. Bradford Scholars (University of Bradford) · 2009
    3. 845 Dermal lymphatic vessels promote hair follicle growth via the BMP inhibitor Sostdc1 Journal of Investigative Dermatology · 2017
    4. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025
    5. 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision Journal of Investigative Dermatology · 2017
    6. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    7. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003 · 176 citations
    8. Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles Health Science Reports · 2022 · 5 citations
    9. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    10. Noggin is required for induction of the hair follicle growth phase in postnatal skin The FASEB Journal · 2001 · 211 citations
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