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    Glossary BMP antagonist

    substance that inhibits Bone Morphogenetic Protein activity

    A BMP antagonist, also known as a Bone Morphogenetic Protein antagonist, is a substance that inhibits the activity of BMPs, which are proteins involved in the regulation of cell growth, differentiation, and development. By blocking BMP signaling, these antagonists can influence various biological processes, including bone formation and hair growth, making them relevant in medical research and treatments for conditions like alopecia and bone disorders.

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    1. Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot Developmental biology · 2003 · 243 citations
    2. Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin. Bradford Scholars (University of Bradford) · 2009
    3. 845 Dermal lymphatic vessels promote hair follicle growth via the BMP inhibitor Sostdc1 Journal of Investigative Dermatology · 2017
    4. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025
    5. 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision Journal of Investigative Dermatology · 2017
    6. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    7. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003 · 176 citations
    8. Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles Health Science Reports · 2022 · 5 citations
    9. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    10. Noggin is required for induction of the hair follicle growth phase in postnatal skin The FASEB Journal · 2001 · 211 citations
    11. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006 · 176 citations
    12. Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop Genes & Development · 2012 · 138 citations
    13. Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes Proceedings of the National Academy of Sciences of the United States of America · 2006 · 92 citations
    14. Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation EMBO journal · 2003 · 65 citations
    15. Sp6 downregulation of follistatin gene expression in ameloblasts Journal of medical investigation · 2008 · 28 citations
    16. Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options Expert Opinion on Therapeutic Targets · 2019 · 19 citations
    17. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018 · 11 citations
    18. Decision letter: A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning 2017
    19. A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth Experimental Dermatology · 2018 · 30 citations
    20. Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation Stem Cell Reviews and Reports · 2026
    21. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proceedings of the National Academy of Sciences · 2013 · 176 citations
    22. Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    23. BMP signaling in the control of skin development and hair follicle growth Differentiation · 2004 · 165 citations
    24. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin The FASEB Journal · 2003 · 81 citations
    25. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    26. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    27. TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling 2023
    28. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004 · 131 citations
    29. Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface ˜The œAmerican journal of pathology · 2008 · 41 citations
    30. The role of Wnt and Shh signaling systems in noggin-induced tumorigenesis Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo · 2024