TLDR Wnt and Shh signaling are key in noggin-induced tumors, and blocking them can slow tumor growth.
The study explores the role of Wnt and Shh signaling in noggin-induced tumorigenesis in hair follicles of transgenic mice. BMP inhibition up-regulates Wnt and Shh signaling, leading to hair follicle-derived tumors. Pharmacological inhibitors of Wnt and Shh pathways significantly slowed tumor formation, indicating their therapeutic potential. BMP4 treatment suppressed Shh expression, showing an antagonistic relationship between BMP and Shh pathways. The research highlights Wnt signaling's role in tumor initiation and Shh signaling's role in tumor growth, suggesting new cancer therapy targets.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
223 citations,
January 2014 in “International Journal of Molecular Sciences” The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.
82 citations,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
102 citations,
August 2008 in “Genes & Development” Laminin-511 is crucial for early hair growth and maintaining important hair development signals.
41 citations,
October 2008 in “The American journal of pathology” Blocking a specific protein signal can make hair grow on mouse nipples.
479 citations,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
