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Glossary Matrix Metalloproteinases

enzymes that degrade extracellular matrix proteins

Matrix Metalloproteinases (MMPs) are a group of enzymes that break down proteins in the extracellular matrix, which is the network of molecules surrounding cells. They play a crucial role in tissue remodeling, wound healing, and various physiological processes, but their overactivity can contribute to diseases like arthritis and cancer.

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research Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation

20 citations , September 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that MMP-9 plays a significant role in extracellular matrix remodeling during hair canal formation in mice, as indicated by delayed hair shaft emergence and hair canal development in MMP-9 knockout mice.

research Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation

56 citations , November 2003 in “Journal of Investigative Dermatology”

This study identified altered expression of MMP-19 in the skin's epidermal layers during diseases like psoriasis and eczema, implying a role in disease processes.

research Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle

21 citations , May 2016 in “Experimental and Therapeutic Medicine”

In this study, the researchers observed that MMP-2 and MMP-9 significantly fluctuated with the hair growth cycle in mice, suggesting their important role in hair development.

research Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts

9 citations , August 2005 in “Archives of Dermatological Research”

Scalp dermal papilla and fibrous sheath cells have different MMP expression than scalp dermal fibroblasts.

research A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women

8 citations , May 2005 in “Fertility and Sterility”

In this study, women with the GG polymorphism of the MMP1 gene promoter were found to have a higher likelihood of being diagnosed with polycystic ovary syndrome.

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