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GlossaryCXCR3

receptor on immune cells guiding them to inflammation sites

CXCR3 is a receptor found on the surface of certain immune cells, such as T cells. It plays a crucial role in directing these cells to sites of inflammation or injury by binding to specific signaling molecules called chemokines. This receptor is important in various immune responses and has been implicated in conditions like autoimmune diseases and alopecia, where the immune system mistakenly attacks the body's own tissues.

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research CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata

64 citations, July 2016 in “Journal of Immunology”

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

research Neutrophils Promote CXCR3-Dependent Itch in the Development of Atopic Dermatitis

1 citations, October 2019

Neutrophils are important for causing chronic itch in atopic dermatitis, and blocking the CXCR3 receptor may reduce this itch.

research Neutrophils Promote CXCR3-Dependent Itch in the Development of Atopic Dermatitis

July 2019

Neutrophils are key in causing chronic itch in atopic dermatitis, and blocking CXCR3 could reduce this itch.

research Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata

52 citations, March 2010 in “British Journal of Dermatology”

Alopecia areata shows a unique type 1 interferon signature, suggesting potential treatment by targeting this pathway.

research Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

48 citations, January 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Chemokine signaling is important for hair development.

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