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Glossary CXCR3

receptor on immune cells guiding them to inflammation sites

CXCR3 is a receptor found on the surface of certain immune cells, such as T cells. It plays a crucial role in directing these cells to sites of inflammation or injury by binding to specific signaling molecules called chemokines. This receptor is important in various immune responses and has been implicated in conditions like autoimmune diseases and alopecia, where the immune system mistakenly attacks the body's own tissues.

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research PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus

71 citations , May 2019 in “Rheumatology”

This study observed that PD-1+CXCR5-CD4+T peripheral helper cells are significantly elevated in patients with systemic lupus erythematosus and are correlated with disease activity indicators, suggesting their potential role in lupus pathogenesis.

research CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata

64 citations , July 2016 in “Journal of Immunology”

In this study, blocking the CXCR3 receptor in mice prevented the development of alopecia areata by inhibiting the accumulation of specific T cells in the skin, suggesting a potential therapeutic approach for humans.

research Author response: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

1 citations , October 2019

This study found that skin-infiltrating neutrophils play a crucial role in triggering chronic itch in atopic dermatitis by promoting skin hyperinnervation and enhanced expression of itch signaling molecules in a mouse model.

research Decision letter: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

July 2019

This study found that neutrophils are crucial for initiating chronic itch in atopic dermatitis and suggest that targeting neutrophils may help alleviate symptoms in this condition.

research Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration

October 2025 in “Cell Reports”

This study found that regulatory T cells accumulate in hair follicle epithelium via the Cxcr4-Cxcl12 axis, partially influenced by glucocorticoid receptor signaling, promoting hair regeneration; similar mechanisms were observed in human and murine skin.

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