Keratinocyte-Specific Ablation of the NF-κB Regulatory Protein A20 (TNFAIP3) Reveals a Role in the Control of Epidermal Homeostasis

    May 2011 in “ Cell death and differentiation ”
    Saskia Lippens, Sylvie Lefebvre, Barbara Gilbert … Geert Loo
    Studysummary This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.
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    Research cited in this study 6

    1. Cell Death in the Skin: Mechanisms and Implications Apoptosis · 2009
    2. Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form Human mutation · 2008
    3. TNF Superfamily in Skin Appendage Development Cytokine & growth factor reviews · 2008
    4. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    5. Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency Molecular and Cellular Biology · 2004
    6. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003