XEDAR Activates the Non-Canonical NF-κB Pathway

    August 2015 in “ Biochemical and Biophysical Research Communications ”
    Kelly Verhelst, Sandra Gardam, Alice Borghi … Rudi Beyaert
    Studysummary This study found that the XEDAR receptor can activate the non-canonical NF-kB pathway involving p100 processing, which is regulated by interactions with TRAF proteins and specific kinases.
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    Research cited in this study 2

    1. EDA2R Is Associated With Androgenetic Alopecia Journal of Investigative Dermatology · 2008
    2. Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency Molecular and Cellular Biology · 2004

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    1. XEDAR Activates the Non-Canonical NF-κB Pathway Biochemical and Biophysical Research Communications · 2015