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research Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

81 citations , February 2014 in “EMBO molecular medicine”

This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.

research Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

76 citations , May 2011 in “Cell death and differentiation”

This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.

research Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins

63 citations , July 2006 in “British Journal of Dermatology”

This study found that keratin K17 is induced in the suprabasal layer of psoriatic scalp epidermis during epidermal hyperproliferation, suggesting it is not specific to hair follicles.

research Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia)

14 citations , July 2015 in “Journal of Cosmetic Dermatology”

This study found that, in Japanese patients with androgenic alopecia, sebaceous glands exhibit increased multilobulation which may be significant in the condition's pathology.

research Specific In Vivo Ablation of Lrig1-Positive Follicular Progenitor Cells Results in Sebaceous Gland Loss in Mice

February 2026 in “International Journal of Molecular Sciences”

In this study, Lrig1-positive stem cells in mouse hair follicles were found to be essential for sebaceous gland formation and maintenance, with their depletion causing a temporary loss of these glands and changes in cellular differentiation.

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community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Derm says my hair loss (diffuse) is from seborrheic dermatitis. Anyone else have experience with this? I was already prepared to jump on fin min

in Research/Science 26 upvotes 1 year ago

Seborrheic dermatitis can cause hair loss, and treatments like ketoconazole shampoo, topical steroids, and oral antifungals may help. Some consider using finasteride and minoxidil for hair loss despite dermatitis.

community possible treatment of AGA and change in sebaceous gland condition and oil production using sulfur soap

in Research/Science 4 upvotes 11 months ago

Sulfur soap may help with hair thickening and reducing scalp inflammation, but it can cause dryness. Nizoral, containing ketoconazole, is noted for its potential to reduce seborrheic dermatitis but may also cause scalp dryness and hair loss.

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