Gas Chromatography/Mass Spectrometry Based Hair Steroid Profiling May Reveal Pathogenesis in Hair Follicles of the Scalp

    April 2011 in “ Rapid communications in mass spectrometry/RCM. Rapid communications in mass spectrometry ”
    Hyun Jin Jung, Sun-Ju Kim, Won Yong Lee … Man Ho Choi
    Studysummary This study found that using hair steroid profiling, dutasteride treatment led to reduced dihydrotestosterone levels and DHT/testosterone ratio in patients with male-pattern baldness.
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    Research cited in this study 17

    1. Hair as a Retrospective Calendar of Cortisol Production—Increased Cortisol Incorporation into Hair in the Third Trimester of Pregnancy Psychoneuroendocrinology · 2008
    2. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    3. Androgens and Hair Growth Dermatologic Therapy · 2008
    4. Sexual Hormones in Human Skin Hormone and metabolic research · 2007
    5. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    6. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    7. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    8. Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia Dermatology · 2003
    9. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    10. Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    11. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001
    12. Biochemical Roles of Testosterone and Epitestosterone to 5α-Reductase as Indicators of Male-Pattern Baldness Journal of Investigative Dermatology · 2001
    13. Determination of Estrone and 17β-Estradiol in Human Hair by Gas Chromatography–Mass Spectrometry The Analyst · 2000
    14. Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells British journal of dermatology/British journal of dermatology, Supplement · 1999
    15. GC-MS Determination of Steroids Related to Androgen Biosynthesis in Human Hair with Pentafluorophenyldimethylsilyl–Trimethylsilyl Derivatisation The Analyst · 1999
    16. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    17. Androgens and Human Hair Growth Clinical endocrinology · 1994

    Related research 1

    1. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994