Cellular Retinol-Binding Protein-1 Expression Increases with Clinical Severity of Alopecia Areata

December 2018 in “ Journal of cosmetic dermatology ”

Eman Hamed Elmaadawy, Lamia Hamouda Elgarhy, Mohammad Shareef

cellular retinol-binding protein-1 CRBP1 alopecia areata AA SALT score

TLDR Higher CRBP1 levels are linked to more severe alopecia areata.

The study investigated the expression of cellular retinol-binding protein-1 (CRBP1) in the skin lesions of 30 alopecia areata (AA) patients compared to 10 healthy controls. It found that CRBP1 expression was significantly higher in AA lesions (P < 0.001) and positively correlated with the severity of hair loss (SALT score; r = 0.840, P < 0.001). These findings suggested that CRBP1 might play a role in the pathogenesis of AA and highlighted its potential importance in AA treatment.

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Research cited in this study

8 / 8 results

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations, September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin A affects hair loss and immune response in alopecia areata.

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

50 citations, September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

research Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

6 citations, June 2011 in “British Journal of Dermatology”

People with alopecia areata have higher levels of RBP4 protein and antibodies against it.

research Phase I/II Randomized Bilateral Half-Head Comparison of Topical Bexarotene 1% Gel for Alopecia Areata

44 citations, October 2009 in “Journal of the American Academy of Dermatology”

Topical bexarotene 1% gel might help regrow hair in alopecia areata and is generally safe.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations, February 2009 in “Journal of biological chemistry/The Journal of biological chemistry”

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations, March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations, June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

research Topical Tretinoin as an Adjunctive Therapy with Intralesional Triamcinolone Acetonide for Alopecia Areata: Clinical Experience in Northern Saudi Arabia

11 citations, April 1997 in “International Journal of Dermatology”

Using tretinoin with triamcinolone acetonide helps treat alopecia areata.

Related Research

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

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A child with rough nails also had hair loss and allergies.

Cellular Retinol-Binding Protein-1 Expression Increases with Clinical Severity of Alopecia Areata

Research cited in this study

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

research Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

research Phase I/II Randomized Bilateral Half-Head Comparison of Topical Bexarotene 1% Gel for Alopecia Areata

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Topical Tretinoin as an Adjunctive Therapy with Intralesional Triamcinolone Acetonide for Alopecia Areata: Clinical Experience in Northern Saudi Arabia

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