Cellular Retinol-Binding Protein-1 Expression Increases with Clinical Severity of Alopecia Areata

December 2018 in “ Journal of cosmetic dermatology ”

Eman Hamed Elmaadawy, Lamia Hamouda Elgarhy, Mohammad Shareef

cellular retinol-binding protein-1 CRBP1 alopecia areata AA SALT score

TLDR Higher CRBP1 levels are linked to more severe alopecia areata.

The study investigated the expression of cellular retinol-binding protein-1 (CRBP1) in the skin lesions of 30 alopecia areata (AA) patients compared to 10 healthy controls. It found that CRBP1 expression was significantly higher in AA lesions (P < 0.001) and positively correlated with the severity of hair loss (SALT score; r = 0.840, P < 0.001). These findings suggested that CRBP1 might play a role in the pathogenesis of AA and highlighted its potential importance in AA treatment.

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