Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update

    Thipprapai Mahasaksiri, Chaninan Kositkuljorn, Tanaporn Anuntrangsee, Poonkiat Suchonwanit
    TLDR Topical immunotherapy can treat alopecia areata, but its effectiveness varies and the exact mechanism is unclear.
    The review discussed the application of topical immunotherapy, particularly diphenylcyclopropenone (DPCP), in treating alopecia areata, highlighting its effectiveness in inducing hair regrowth by modulating immune responses. Studies, including a large retrospective study with 757 patients, showed positive outcomes with DPCP, though success varied among patients. Side effects such as contact dermatitis, pigmentation abnormalities, urticaria, erythema multiforme major, and scalp angioedema were common. The review emphasized the need for further research to optimize treatment protocols, minimize adverse effects, and understand long-term outcomes. Home-based DPCP treatment was found to be as effective and safe as clinic-based treatment, improving patient compliance.
    Discuss this study in the Community →

    Research cited in this study

    45 / 45 results

    Related Community Posts Join

    6 / 1000+ results

      community Roughly one year on finasteride

      in Progress Pictures  515 upvotes 1 year ago
      The conversation is about someone's positive experience with 0.5 mg of finasteride daily for hair loss, noting potential contributions from vitamins and health improvements. Side effects and observations from others include watery semen and questions about hair regrowth and shedding phases.

      community Topical 5% Min - 2% Keto shampoo - 4 months update - 26M out

      in Is this regrowth?  10 upvotes 1 week ago
      A 26-year-old male experiencing hair loss since 2020 is using topical 5% Minoxidil and 2% Ketoconazole shampoo for four months, still experiencing significant shedding. He is considering cutting his hair short and has not yet started DHT blockers like Finasteride or Dutasteride.

      community Topical Finasteride 2 year update

      in Progress Pictures  884 upvotes 2 weeks ago
      The user reported significant improvement in hair quality and stability using topical finasteride for two years, without side effects. They later added minoxidil, which may have further enhanced hair quality.

    Related Research

    1 / 1 results