Efficacy and Safety of Anthralin in Combination with Diphenylcyclopropenone in the Treatment of Alopecia Areata: A Retrospective Case Series

June 2019 in “ Archives of dermatological research ”

Maryam Nasimi, Narges Ghandi, Robabeh Abedini, Azadeh Mirshamsi, Safoura Shakoei, Sk. Sarif Hassan

anthralin diphenylcyclopropenone alopecia areata terminal hair regrowth bullae pruritus DPCP

TLDR Combining DPCP and anthralin helps regrow hair in some alopecia areata patients.

In a retrospective case series involving 32 alopecia areata patients unresponsive to diphenylcyclopropenone (DPCP) alone, a combination of DPCP and anthralin over an average of 8.3 months resulted in 40.62% of patients experiencing terminal hair regrowth, with a mean regrowth rate of 41%. Additionally, 27.27% of patients achieved more than 50% terminal hair regrowth. The study found a strong correlation between longer treatment durations and better outcomes (p < 0.001). The most common side effect was bullae (25%), while generalized pruritus was the least frequent (3.1%). The combination therapy was effective for DPCP non-responder AA patients.

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research Alopecia Areata: Treatment Options and Efficacy

182 citations , January 2018 in “Journal of the American Academy of Dermatology”

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

research Systematic Review and Quality Analysis of Studies on the Efficacy of Topical Diphenylcyclopropenone Treatment for Alopecia Areata

21 citations , July 2017 in “Journal of The American Academy of Dermatology”

Topical DPCP is somewhat effective for hair loss in alopecia areata, but more research is needed.

research Higher Concentrations of Dithranol Appear to Induce Hair Growth Even in Severe Alopecia Areata

12 citations , June 2017 in “Dermatologic therapy”

Higher concentrations of dithranol can help regrow hair in severe alopecia areata.

research Possible Advantage of Imiquimod and Diphenylcyclopropenone Combined Treatment Versus Diphenylcyclopropenone Alone: An Observational Study of Nonresponder Patients With Alopecia Areata

9 citations , April 2016 in “Australasian journal of dermatology”

Combining imiquimod with diphenylcyclopropenone may improve treatment outcomes for alopecia areata patients who don't respond to diphenylcyclopropenone alone.

research Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

44 citations , April 2015 in “Journal of the American Academy of Dermatology”

Combining diphenylcyclopropenone with anthralin is more effective for hair regrowth in alopecia areata than using diphenylcyclopropenone alone, but may cause more side effects.

research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

218 citations , May 2012 in “British Journal of Dermatology”

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

research Alopecia Areata Update

391 citations , February 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Alopecia Areata Update

244 citations , February 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research Interventions for Alopecia Areata

164 citations , April 2008 in “Cochrane library”

Current treatments for alopecia show no significant long-term benefits.

research Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone

27 citations , May 2007 in “Archives of dermatological research”

Diphencyprone treatment increases CD8 lymphocytes in the scalp, which is associated with hair regrowth in alopecia areata patients.

research Treatment of chronic severe alopecia areata with topical diphenylcyclopropenone and 5% minoxidil: A clinical and immunopathologic evaluation

41 citations , November 1993 in “Journal of The American Academy of Dermatology”

DPCP helps treat severe hair loss, but 5% minoxidil doesn't add benefits.

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.

Efficacy and Safety of Anthralin in Combination with Diphenylcyclopropenone in the Treatment of Alopecia Areata: A Retrospective Case Series

Cited in this study

research Alopecia Areata: Treatment Options and Efficacy

research Systematic Review and Quality Analysis of Studies on the Efficacy of Topical Diphenylcyclopropenone Treatment for Alopecia Areata

research Higher Concentrations of Dithranol Appear to Induce Hair Growth Even in Severe Alopecia Areata

research Possible Advantage of Imiquimod and Diphenylcyclopropenone Combined Treatment Versus Diphenylcyclopropenone Alone: An Observational Study of Nonresponder Patients With Alopecia Areata

research Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

research Alopecia Areata Update

research Alopecia Areata Update

research Interventions for Alopecia Areata

research Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone

research Restoration of Hair Growth in Mice with an Alopecia Areata-Like Disease Using Topical Anthralin

research Old Wine in New Bottles: Reviving Old Therapies for Alopecia Areata Using Rodent Models

research The Therapeutic Use of Topical Contact Sensitizers in Benign Dermatoses

research Treatment of chronic severe alopecia areata with topical diphenylcyclopropenone and 5% minoxidil: A clinical and immunopathologic evaluation

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