Old Wine in New Bottles: Reviving Old Therapies for Alopecia Areata Using Rodent Models

    September 2003 in “ Journal of Investigative Dermatology Symposium Proceedings ”
    Lisa Tang, John P. Sundberg, Harvey Lui, Jerry Shapiro
    Studysummary This study found that anthralin and mechlorethamine were the most effective therapies among those tested in AA-affected rodent models, providing a basis for further analysis of their mechanisms in Alopecia Areata.
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    Research cited in this study 10

    1. Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes Journal of Investigative Dermatology · 2003
    2. Role of Cytotoxic T Cells in Chronic Alopecia Areata Journal of Investigative Dermatology · 2000
    3. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    4. Hair Regrowth Dermatologic Clinics · 1998
    5. Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss Journal of Investigative Dermatology · 1997
    6. Genetic Control of Cytokines Dermatologic clinics · 1996
    7. The Pathogenesis of Alopecia Areata Dermatologic Clinics · 1996
    8. Mouse Models for the Study of Human Hair Loss Dermatologic Clinics · 1996
    9. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994
    10. Evaluation of Anthralin in the Treatment of Alopecia Areata Archives of dermatology · 1987