Genetic Control of Cytokines

October 1996 in “ Dermatologic clinics ”

Michael J. Cork, Alison M. Crane, Gordon W. Duff

cytokines interleukin 1 IL 1 keratinocytes epidermis dermal papilla hair growth alopecia areata gene polymorphisms inflammatory response cytokines IL 1 skin cells skin hair follicle cells hair loss genetic variations inflammation

TLDR Genes affect cytokine production, which can influence chronic diseases, and certain interventions may help prevent related molecular damage.

The document discussed the genetic control of cytokines, particularly focusing on interleukin 1 (IL 1) and its role in immune response and hair growth regulation. IL 1, produced mainly by keratinocytes in the skin, was found in significantly higher levels in the epidermis compared to other tissues. The study highlighted the importance of the dermal papilla in hair growth and the potential impact of IL 1 gene polymorphisms on alopecia areata. It concluded that alopecia areata is a multifactorial disease influenced by both genetic and environmental factors, with cytokine regulation playing a crucial role in the inflammatory response and clinical outcomes.

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