Transgenic Mice Overexpressing CD109 in the Epidermis Display Decreased Inflammation and Granulation Tissue and Improved Collagen Architecture During Wound Healing
February 2013
in “
Wound Repair and Regeneration
”
CD109 epidermis inflammation granulation tissue collagen architecture wound healing TGF-β macrophage neutrophil cytokines Smad2 Smad3 dermal architecture incisional wounds tensile strength therapeutic target scarring skin wound repair immune cells healing process skin structure healing strength healing improvement
Studysummary In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.
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