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    Integrated-Omics Profiling Unveils the Disparities of Host Defense to ECM Scaffolds During Wound Healing in Aged Individuals

    December 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Shuaidong Chen, Chenbing Wang, Yi Man, Chenyu Chu

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study observed that extracellular matrix scaffold membranes performed less effectively in wound healing for aged mice compared to younger ones, with senescent SPP1+ macrophages potentially hindering epidermal and fibroblast repair abilities.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration Nature Communications · 2023
    2. Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging Nature Aging · 2023
    3. Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    4. Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing Science Advances · 2021
    5. Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing Nature Materials · 2020
    6. Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature Journal of Investigative Dermatology · 2017
    7. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    8. Elevated Circulation Levels of an Antiangiogenic SERPIN in Patients with Diabetic Microvascular Complications Impair Wound Healing Through Suppression of Wnt Signaling Journal of Investigative Dermatology · 2014