Multimodal Roles of Transient Receptor Potential Channel Activation in Inducing Pathological Tissue Scarification

This review examines the role of transient receptor potential (TRP) channels in pathological scarification (PS), a condition marked by excessive fibrosis and inflammation during wound healing. TRP channels, including TRPV, TRPC, TRPA, and TRPM, are crucial in immune cell activation, cytokine release, and fibroblast activity, contributing to fibrosis and re-epithelialization. The review suggests that targeting TRP channels could inhibit PS by affecting mechanical conduction, oxidative stress, and immune responses. Specific channels like TRPV1, TRPV2, TRPV3, TRPV4, TRPC3, and TRPC6 are highlighted for their roles in inflammation, fibrosis, and pruritus, with potential therapeutic strategies involving their inhibition. The document underscores the need for further research into TRP channels to develop targeted treatments for PS.