Macrophages in Skin Wounds: Functions and Therapeutic Potential

    November 2022 in “ Biomolecules ”
    Seen Ling Sim, Snehlata Kumari, Simranpreet Kaur, Kiarash Khosrotehrani
    Studysummary This review explores the role of macrophage subsets in adult cutaneous wound healing and emphasizes their potential for therapeutic targeting, but reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    2. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020
    3. Wound Healing: Cellular Mechanisms and Pathological Outcomes Open Biology · 2020
    4. Role of Regulatory T Cells in Psoriasis Pathogenesis and Treatment British Journal of Dermatology · 2020
    5. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    6. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    7. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    8. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner Journal of Investigative Dermatology · 2018
    9. Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature Journal of Investigative Dermatology · 2017
    10. Toll-Like Receptor Function in Acute Wounds Advances in wound care · 2017
    11. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    12. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    13. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005