Macrophages in Skin Wounds: Functions and Therapeutic Potential

November 2022 in “ Biomolecules ”

Seen Ling Sim, Snehlata Kumari, Simranpreet Kaur, Kiarash Khosrotehrani

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research Bacteria Induce Skin Regeneration via IL-1β Signaling

53 citations , April 2021 in “Cell Host & Microbe”

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

research An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

23 citations , December 2020 in “Frontiers in Cell and Developmental Biology”

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

research Wound healing: cellular mechanisms and pathological outcomes

1425 citations , September 2020 in “Open Biology”

Better understanding of wound healing is needed to develop effective treatments for chronic wounds.

research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

101 citations , March 2019 in “Cell Stem Cell”

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

research Wound Healing: A Cellular Perspective

1160 citations , November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

research Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner

36 citations , April 2018 in “Journal of Investigative Dermatology”

Macrophages help hair growth after injury through CX3CR1 and TGF-β1.

research Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature

26 citations , December 2017 in “Journal of Investigative Dermatology”

Disrupting Notch signaling in blood vessels increases scarring during wound healing in mice.

research Toll-Like Receptor Function in Acute Wounds

65 citations , May 2017 in “Advances in wound care”

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.