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GlossaryTransient Receptor Potential Channels (TRP channels)

ion channels involved in sensory perception and physiological processes

Transient Receptor Potential (TRP) channels are a group of ion channels located in the cell membrane that play a crucial role in various physiological processes, including sensation and temperature regulation. These channels respond to a wide range of stimuli, such as temperature changes, pH levels, and mechanical stress, and are involved in sensory functions like pain perception and taste.

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research TRP Channels in Skin Biology and Pathophysiology

124 citations , December 2016 in “Pharmaceuticals”

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

research Effects of Transient Receptor Potential (TRP) Channel Agonists and Antagonists on Slowly Adapting Type II Mechanoreceptors in the Rat Sinus Hair Follicle

13 citations , December 2009 in “Journal of the Peripheral Nervous System”

TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.

research Multimodal Roles of Transient Receptor Potential Channel Activation in Inducing Pathological Tissue Scarification

7 citations , August 2023 in “Frontiers in Immunology”

Targeting TRP channels may help reduce excessive scarring.

Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

research The Itchy Scalp: Scratching for an Explanation

61 citations , October 2011 in “Experimental dermatology”

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

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