Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging

June 2023 in “ Nature Aging ”

Paloma Solá, Elisabetta Mereu, Júlia Bonjoch, Marta Casado-Peláez, Neus Prats, Mònica Aguilera, Óscar Reina, Enrique Blanco, Manel Esteller, Luciano Di Croce, Holger Heyn, Guiomar Solanas, Salvador Aznar Benitah

IL-17 signaling T helper cells γδ T cells innate lymphoid cells proinflammatory state NF-κB epidermal cells

TLDR Blocking IL-17 signaling may reduce skin inflammation and delay aging.

The study investigates the role of IL-17 signaling in skin aging, revealing that aged skin exhibits a shift towards an IL-17-expressing phenotype in T helper cells, γδ T cells, and innate lymphoid cells. This shift contributes to a proinflammatory state, which is linked to age-related skin changes. By blocking IL-17 signaling in vivo, researchers observed a reduction in skin inflammation and a delay in aging traits. The findings suggest that IL-17 signaling, which disrupts homeostatic functions through NF-κB in epidermal cells, could be a target for preventing age-associated skin issues.

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations , February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

research Mechanisms Regulating Skin Immunity and Inflammation

610 citations , April 2014 in “Nature Reviews Immunology”

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

Two fibroblast types shape skin structure and repair differently.

research Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche

133 citations , September 2013 in “Nature Reviews Molecular Cell Biology”

Different types of stem cells and their environments are key to skin repair and maintenance.

research Age-Associated Inflammation Inhibits Epidermal Stem Cell Function

144 citations , September 2012 in “Genes & development”

Aging causes skin stem cells to work less effectively.

research Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis

78 citations , October 2007 in “Journal of Investigative Dermatology”

Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.

Related Community Posts Join

6 / 117 results

community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 2 weeks ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

in Research/Science 135 upvotes 3 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community 8 years of hair loss, turning 30 next month

in Progress Pictures 149 upvotes 6 months ago

The user has been dealing with hair loss for 10 years, worsened by psoriasis, and uses minoxidil and finasteride. They seek advice on managing psoriasis and hair loss, with suggestions to see a dermatologist, try different shampoos, and be patient.

community We really out here with a subscription service for our hair...

in Satire 324 upvotes 2 years ago

Hair loss discussion mentions using Minoxidil, Finasteride, and RU58841. Users compare subscription services for hair treatments to other daily necessities and discuss cheaper alternatives.

Similar Research

5 / 1000+ results

Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes