Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging

June 2023 in “ Nature Aging ”

Paloma Solá, Elisabetta Mereu, Júlia Bonjoch, Marta Casado-Peláez, Neus Prats, Mònica Aguilera, Óscar Reina, Enrique Blanco, Manel Esteller, Luciano Di Croce, Holger Heyn, Guiomar Solanas, Salvador Aznar Benitah

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research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

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research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations , February 2016 in “Science”

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research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

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research Mechanisms Regulating Skin Immunity and Inflammation

610 citations , April 2014 in “Nature Reviews Immunology”

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

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research Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche

133 citations , September 2013 in “Nature Reviews Molecular Cell Biology”

Different types of stem cells and their environments are key to skin repair and maintenance.

research Age-Associated Inflammation Inhibits Epidermal Stem Cell Function

144 citations , September 2012 in “Genes & development”

Aging causes skin stem cells to work less effectively.

research Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis

78 citations , October 2007 in “Journal of Investigative Dermatology”

Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.