Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging

    June 2023 in “ Nature Aging ”
    Paloma Solá, Elisabetta Mereu, Júlia Bonjoch, Marta Casado-Peláez, Neus Prats, Mònica Aguilera, Óscar Reina, Enrique Blanco, Manel Esteller, Luciano Di Croce, Holger Heyn, Guiomar Solanas, Salvador Aznar Benitah
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    Studysummary This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigates the role of IL-17 signaling in skin aging, revealing that aged skin exhibits a shift towards an IL-17-expressing phenotype in T helper cells, γδ T cells, and innate lymphoid cells. This shift contributes to a proinflammatory state, which is linked to age-related skin changes. By blocking IL-17 signaling in vivo, researchers observed a reduction in skin inflammation and a delay in aging traits. The findings suggest that IL-17 signaling, which disrupts homeostatic functions through NF-κB in epidermal cells, could be a target for preventing age-associated skin issues.
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