Efficacy of Topical Diphenylcyclopropenone Maintenance Treatment for Patients with Alopecia Areata: A Retrospective Study

January 2018 in “ Journal of the American Academy of Dermatology ”

Sung Jay Choe, Solam Lee, Hanil Lee, Jinseok Choi, Won‐Soo Lee

diphenylcyclopropenone DPCP alopecia areata hair regrowth relapse rate Kaplan-Meier analysis Cox regression analysis AA

TLDR Diphenylcyclopropenone treatment helps prevent hair loss relapse in alopecia areata patients.

This retrospective study evaluated the efficacy of diphenylcyclopropenone maintenance treatment (DPCP-MT) in preventing relapse in 63 patients with alopecia areata (AA) who had achieved >90% hair regrowth. The relapse rate (RR) was significantly lower in the maintenance-treated group (24.4%) compared to the maintenance-untreated group (68.2%). Kaplan-Meier and Cox regression analyses indicated that DPCP-MT was an independent prognostic factor for lower relapse rates. The study suggested that DPCP-MT could maintain AA remission, emphasizing the importance of carefully adjusting treatment intervals after clinical improvement. Limitations included the small sample size and retrospective design.

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Research cited in this study

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Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

research Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

44 citations, February 2015 in “Journal of the American Academy of Dermatology”

Combining diphenylcyclopropenone with anthralin is more effective for hair regrowth in alopecia areata than using diphenylcyclopropenone alone, but may cause more side effects.

research Alopecia Areata Update

244 citations, January 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research Five-Year Experience in the Treatment of Alopecia Areata with Diphencyprone

37 citations, September 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Diphencyprone (DPC) is an effective and safe long-term treatment for alopecia areata, especially with maintenance therapy.

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research Serum Zinc Concentration in Patients With Alopecia Areata

October 2023 in “Acta dermato-venereologica (Print)”

People with severe hair loss have lower zinc levels in their blood.