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research Severe alopecia areata treated with systemic corticosteroids

30 citations , August 1998 in “International Journal of Dermatology”

This study found that systemic corticosteroids led to satisfactory hair regrowth in 38.9% of severe alopecia areata patients, but hair fall occurred upon therapy discontinuation or tapering.

research Th1/Th2 PB balance and CD200 expression of patients with active severe alopecia areata

12 citations , April 2017 in “Experimental and Therapeutic Medicine”

This study found that patients with active severe alopecia areata exhibited decreased CD200 expression on T and B lymphocytes, which may be linked to an imbalance in Th1/Th2 immune equilibrium.

research Upadacitinib Therapy in Adolescent Severe Alopecia Areata: A Case Series and Narrative Review

1 citations , September 2025 in “Clinical Cosmetic and Investigational Dermatology”

Upadacitinib is effective and safe for treating severe Alopecia Areata in adolescents.

research 75392 Psychosocial Burden of Severe Pediatric Alopecia Areata and Strategies for Mitigation: A Narrative Evidence Synthesis

July 2026 in “Journal of the American Academy of Dermatology”

Severe alopecia areata in children greatly affects their mental and social well-being, and addressing these challenges is crucial.

research Severe Alopecia caused by Azathioprine in Systemic Lupus Erythematosus.

July 2025 in “PubMed”

This case report details a 45-year-old woman with SLE who experienced severe leukopenia and hair loss attributed to azathioprine, suggesting the importance of recognizing these potential adverse effects for timely intervention.

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Community Join

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community After the blood test I saw I had a severe Vitamin D deficiency.I had androgenic alopecia so I started with minoxidil and finesteride topically along with vitamin D and biotin.

4 upvotes 8 months ago

The user treated androgenic alopecia with topical minoxidil, finasteride, vitamin D, and biotin, while also using ketoconazole shampoo for dandruff. They focus on weight training and take daily vitamin D tablets.

community Severe Hair Loss Post-Surgery and Stress, Possible DUPA or Alopecia?

in General 64 upvotes 10 months ago

The user is experiencing severe hair loss after surgery and stress, with thinning all over the head, including the sides and neck. They are unsure if it's due to DUPA or alopecia areata incognita, and doctors have not observed miniaturization.

community Severe copper deficiency, and also zinc deficiency. Looking for testimonials.

2 upvotes 9 months ago

A 36-year-old man with androgenetic alopecia suspects copper and zinc deficiencies may be accelerating hair loss and is supplementing copper to address this. He is also monitoring blood sugar levels due to previous prediabetes concerns and plans to test for insulin resistance.

community Getting blindsided by atypical aggressive form of androgenetic alopecia in early 20s and realizing it's too late is one of the Top 10 worst male Experiences of all time

in Chat 34 upvotes 11 months ago

A young man faces severe hair loss in his early 20s, using treatments like dutasteride and minoxidil with little success, impacting his self-esteem and relationships. He considers hair systems and therapy as potential solutions.

community Efficacy and Safety of Oral Dutasteride 0.5 mg Combined with Oral Minoxidil 2.5 mg for Male Androgenetic Alopecia: A Retrospective Cohort Study

93 upvotes 1 month ago

Oral dutasteride 0.5 mg combined with oral minoxidil 2.5 mg is highly effective for male androgenetic alopecia, showing over 60% improvement and 98% stabilization at 6 months, with low adverse event rates. Patients with severe baseline conditions respond better and faster to this treatment.

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Learn

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learn Scalp Micropigmentation

Is scalp micropigmentation suitable for all types of hair loss? Scalp micropigmentation is generally suitable for various types of hair loss.
Can scalp micropigmentation hide my scars? Scalp micropigmentation can significantly reduce the visibility of scars on the scalp.
What is Scalp Micropigmentation and how does it help people with visible hair loss? Scalp Micropigmentation creates the illusion of hair follicles on the scalp for visible hair loss.

learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

What is tofacitinib, and why is it discussed in relation to autoimmune-related hair loss such as alopecia areata? Tofacitinib is a prescription JAK inhibitor approved for rheumatoid arthritis, psoriatic arthritis and ulcerative colitis — not for alopecia areata. It is discussed for hair loss because a 2014 case report and a 2016 open-label trial reported regrowth in severe alopecia areata, but that use is off-label, the regrowth relapsed after stopping, and the drug carries an FDA boxed warning.
What types of hair loss conditions are most commonly associated with tofacitinib use in clinical settings? Published studies link tofacitinib mainly to alopecia areata and its severe variants — as an off-label drug being studied for them, not as a cause of hair loss. The evidence is mostly small, open-label or retrospective, and relapse after stopping is commonly reported.

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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