Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

    April 2020 in “ Dermatology and therapy
    Elisa Molinelli, Anna Campanati, Valerio Brisigotti, Claudia Sapigni, Matteo Paolinelli, Annamaria Offidani
    Image of study
    TLDR Calcipotriol works almost as well as clobetasol for mild to moderate alopecia areata with fewer side effects.
    In a study from April 27, 2020, involving 35 patients with scalp alopecia areata (AA), the efficacy and safety of calcipotriol 0.005% ointment, a synthetic vitamin D derivative, was compared to clobetasol 0.05%, a corticosteroid, using an intrasubject design. The study found that patches treated with calcipotriol showed a greater and faster response than those treated with clobetasol, but the differences were not statistically significant. The study was prospective in design but was limited by the small sample size. Calcipotriol was deemed reasonably effective for mild to moderate patchy AA with limited and reversible side effects.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 10 results

      community One year of progress (Fin, 1mg)

      in Is this regrowth?  281 upvotes 3 months ago
      The user started finasteride (1mg) a year ago for hair thinning, experiencing stabilization but not significant regrowth. Suggestions included adding minoxidil, microneedling, and considering a hair transplant for improved results.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  407 upvotes 2 weeks ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  46 upvotes 1 week ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Using topical vitamin D, does it make sense?

      in Chat  6 upvotes 2 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

    Similar Research

    5 / 547 results