Alopecia Areata: A Possible Extraintestinal Manifestation of Crohn's Disease

June 2012 in “ Journal of Crohn's and colitis ”

G. Giannotti, Anna Campanati, Annamaria Offidani

Alopecia Areata non-scarring hair loss CD4+ T lymphocytes CD8+ T lymphocytes Th1 cytokine profile IFN-γ IL-1 TNF-α inflammatory bowel diseases Crohn's disease AA hair loss immune response cytokines inflammation

TLDR Alopecia Areata might be linked to Crohn's disease.

The document discussed Alopecia Areata (AA) as a chronic inflammatory hair disease characterized by non-scarring hair loss, potentially linked to an abnormal immune response involving CD4+ and CD8+ T lymphocytes. It highlighted the significant role of the Th1 cytokine profile, with increased levels of IFN-γ, IL-1, and TNF-α in AA patients compared to healthy controls. The document also suggested a possible connection between AA and inflammatory bowel diseases (IBD), such as Crohn's disease, indicating that AA might be an extraintestinal manifestation of IBD.

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