Videocapillaroscopic Pattern of Alopecia Areata Before and After Diphenylcyclopropenone Treatment

October 2011 in “ International Journal of Immunopathology and Pharmacology ”

Giulia Ganzetti, Anna Campanati, Oriana Simonetti, Ivana Cataldi, Katia Giuliodori, Annamaria Offidani

diphenylcyclopropenone alopecia areata videodermatoscopy intravital videocapillaroscopy exclamation point hairs yellow dots vellus hairs neoangiogenesis DPCP

Studysummary This study found that after 24 weeks of DPCP treatment for alopecia areata, there was a significant increase in new capillaries and hair regrowth detectable by videocapillaroscopy. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of diphenylcyclopropenone (DPCP) treatment on 20 patients with alopecia areata using videodermatoscopy and intravital videocapillaroscopy. Initially, patients exhibited typical alopecia areata features such as "exclamation point" hairs and "yellow dots." After 24 weeks of DPCP treatment, there was a significant reduction in these features and an increase in vellus hairs. Videocapillaroscopy showed a significant increase in new capillaries, indicating neoangiogenesis, which correlated with improved hair regrowth. The study concluded that DPCP therapy led to detectable neoangiogenesis, suggesting a compensatory mechanism for capillary loss in alopecia areata.

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