TLDR The combination of vitamin D analogues with potent steroids is a favorable treatment for alopecia areata with fewer side effects.
The study involved 60 patients with mild to moderate Alopecia Areata, divided into three groups of 20. Each group used a different treatment: topical tacrolimus 0.03%, a mix of topical calcipotriol 0.005% and betamethasone dipropionate, and topical clobetasol 0.05%. All treatments were applied twice daily for 3 months. The results showed significant decreases in positive pull test frequency and SALT scores post-treatment in all groups. Dermovate (clobetasol) had the highest hair regrowth rate (98%), followed by Daivobet (calcipotriol and betamethasone dipropionate) (89%), and tacrolimus (13%). However, at the 3-month follow-up, relapse was noted in 66% of patients treated with tacrolimus, 36.2% with Daivobet, and 25% with Dermovate. The study concluded that Daivobet was as effective as Dermovate, but with fewer side effects, making it more suitable for long-term use. Tacrolimus was not recommended due to its lower efficacy and higher relapse rate.
Cited in this study
9 / 9 results
June 2022 in “Pakistan Journal of Medical and Health Sciences” Topical clobetasol propionate 0.05% ointment is more effective in promoting hair regrowth in patients with alopecia areata than topical tacrolimus 0.1% ointment.
1 citations
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January 2021 in “Journal of clinical and diagnostic research” Using Calcipotriol with Clobetasol is more effective for treating Alopecia Areata than using Clobetasol alone.
23 citations
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November 2020 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” Tailored treatments for alopecia areata are recommended based on severity and patient needs.
10 citations
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April 2020 in “Dermatology and therapy” Calcipotriol works almost as well as clobetasol for mild to moderate alopecia areata with fewer side effects.
37 citations
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December 2019 in “Giornale italiano di dermatologia e venereologia” The Italian guidelines offer advice for diagnosing and treating alopecia areata based on expert opinion and limited clinical trial evidence.
9 citations
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June 2019 in “Archives of Dermatological Research” Both topical calcipotriol and narrowband UVB improved alopecia, but combining them didn't enhance the effect on hair loss severity, despite higher vitamin D3 levels.
1 citations
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January 2019 in “Elsevier eBooks” Alopecia Areata is an autoimmune hair loss condition, with various treatments showing mixed effectiveness and no guaranteed cure.
218 citations
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May 2012 in “British Journal of Dermatology” Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.
13 citations
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June 2010 in “Journal of dermatological treatment” Diphencyprone is effective for treating patchy hair loss in alopecia areata, but tacrolimus is not.