Alopecia Areata and Vitamin D3 Deficiency: The Potential of Calcipotriol as a Treatment

Alopecia areata, affecting 2% of the population, is linked to vitamin D3 deficiency, which is more common in affected individuals and correlates with disease severity. While vitamin D3 plays a role in immune regulation and hair follicle health, current evidence on the effectiveness of vitamin D3 supplementation and topical calcipotriol for treating alopecia areata is inconsistent and of low quality. The article highlights the necessity for large-scale, randomized, placebo-controlled studies to assess the potential of calcipotriol as a treatment for this condition.